New Antibodies for Prostate Cancer Applications

Caspase-3 (RM250), RMab

Abnormal Caspase-3 antibody expression has been directly associated with acute Myelogenous Leukemia, where Caspase-3 overexpression has been detected. On the contrary, decreased expression of Caspase-3 has been found in Prostate Cancer.

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tmprss2 anti-tmprss2 antibody immunohistochemistry ihc

TMPRSS2 (BSB-136), MMab

TMPRSS2 antibody is expressed in the GI tract, stomach, kidney and in the lung epithelium, where it may cleave epithelial sodium channels.

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New Antibodies for Sarcoma and Soft Tissue Cancer Applications

PAX-7 (BSB-145), MMab

PAX-7 antibody is a novel marker, because it was expressed consistently in Ewing sarcoma, in addition to rhabdomyosarcoma and synovial sarcoma.

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tle-1, anti-tle-1, TLE1, anti-TLE1, anti TLE1, Enhancer of split groucho-like protein 1 (ESG1), anti-Enhancer of split groucho-like protein 1 (ESG1), anti Enhancer of split groucho-like protein 1 (ESG1), C230057C06Rik, Grg 1, GRG1, groucho related protein 1, transducin like enhancer of split 1 homolog of Drosophila E spl, Transducin like enhancer protein 1,

TLE1 (BSB-142), MMab

TLE1 antibody can be used to differentiate synovial sarcoma from other sarcomas, including histologically similar tumors such as malignant peripheral nerve sheath tumor.

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New Antibodies for Hodgkin’s and NHD Lymphoma Applications

CD137 / TNFRSF9 (BSB-159), MMab

CD137 (TNFRSF9) antibody positive IHC staining if seen in a majority of Classical Hodgkin Lymphoma (CHL) tissues, indicating its usefulness as a diagnostic biomarker for CHL, it has also been found to be a highly specific immunohistochemical marker of Neoplastic Follicular Dendritic Cells.

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TIA-1 (RBT-TIA1), RMab

The expression of TIA-1 antibody has been studied in anaplastic large cell lymphomas (ALCL), NK-cell lymphomas, peripheral T-cell lymphomas, T-cell lymphocytosis, B-cell lymphomas and lymphoblastic leukemia, and Hodgkin’s lymphoma, etc.

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New Antibodies for Cervical Cancer Applications

cyclin b1 anti-cyclin b1 cyclin-b1 anti cdk1 anti-cdk1 antibody immunohistochemistry

Cyclin B1 (RM281), RMab

Cyclin B1 contributes to the switch-like all or none behavior of the cell in deciding to commit mitosis. Its activation is well regulated, and positive feedback loops ensure that once the cyclin B1-Cdk1 complex is activated it is not deactivated. Cyclin B1 antibody overexpression has been detected in various tumor types.

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p16 (RM267), RMab

p16 is a tumor suppresor gene, important in regulating the cell cycle by binding and deactivating various cyclin-CDK complexes.

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New Antibodies for Melanoma & Skin Cancer Applications

MTAP (RBT-MTAP), RMab

IHC has been found to be an accurate and useful diagnostic method for detecting MTAP deficiency in NSCLC, and the frequency of MTAP deficiency was found to be relatively high.

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New Antibodies for Ovarian Cancer Applications

ARID1A (EP303), RMab

Loss of ARID1A function as shown by loss of expression, presumably due to mutations, is an early molecular event, occurring before malignant transformation, in the development of the majority of Ovarian Clear Cell and Endometrioid Carcinomas arising in Endometriomas.

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FOXL2 (Polyclonal), RPab

FOXL2 antibody is a relatively sensitive and highly specific marker for Sex Cord-Stromal Tumors (SCST). FOXL2 antibody expression is present in almost all SCSTs with a FOXL2 mutation or without a mutation.

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New Antibodies for Germ Cell Cancer Applications

New Antibodies for Infectious Disease Applications

HHV-8 (RBT-HHV8), RMab

HHV-8 antibody is associated with Kaposi’s sarcoma (KS), primary effusion lymphoma, and multicentric Castleman’s disease.

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New Antibodies for Mesothelioma Applications

calretinin anti-calretinin antibody ihc immunohistochemistry

Calretinin (RM324), RMab

Calretinin antibody is expressed in the central and peripheral nervous system and in many normal and pathological tissues. It stains Mesothelioma and can be used to help differentiate lung tumors.

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HEG1 (SKM9-2), MMab

HEG1 antibody has been found to be a highly specific and sensitive marker of epithelioid Malignant Mesothelioma and offers sensitivity comparable to conventional markers for Epithelioid Mesotheliomas, but provides considerably better specificity,

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MTAP (RBT-MTAP), RMab

IHC has been found to be an accurate and useful diagnostic method for detecting MTAP deficiency in NSCLC, and the frequency of MTAP deficiency was found to be relatively high.

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New Antibodies for Kidney & Urothelial Cancer Applications

FGFR-3 (BSB-150), MMab

In addition to high prevalence in Bladder Cancer, somatic mutations in the FGFR3 gene have been associated with Multiple Myeloma and Cervical Cancer.

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New Antibodies for Leukemia & Histiocytic Cancer Applications

Caspase-3 (RM250), RMab

Abnormal Caspase-3 antibody expression has been directly associated with acute Myelogenous Leukemia, where Caspase-3 overexpression has been detected. On the contrary, decreased expression of Caspase-3 has been found in Prostate Cancer.

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cd5 anti-cd5 antibody immunohistochemisry ihc

CD5 (RM314), RMab

CD5 antibody expression is found in T-lymphocyte subsets and is modulated during cellular activation; however, it does not react with granulocytes or monocytes.

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MNDA (BSB-157), MMab

MNDA antibody expression is studied mainly in leukemias and lymphomas. MNDA antibody is a marker to distinguish Nodal Marginal Zone Lymphoma from Follicular Lymphoma, and has been shown to be downregulated inMyelodysplastic Syndrome, a precursor for Leukemia.

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New Antibodies for Thyroid and Parathyroid Cancer Applications

HMGA2 (EP398), RMab

HMGA2 is expressed in most conventional and intramuscular lipomas and can aid in differentiating between Lipomas from dedifferentiated Liposarcomas and distinguishing areas of tumor from normal adipose tissue.

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Trop-2 / EGP-1 (BSB-148), MMab

In Thyroid Cancer cell invasion, Trop-2 signal transduction has been seen as a downstream effect of the ERK and JNK pathways, where its signaling enhances stem cell-like properties of cancer cells, as Trop-2 (EGP-1) regulates proliferation and self-renewal through-catenin signaling.

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New Antibodies for Colon & GI Cancer Applications

Claudin-7 (EP399), RMab

While Claudin-7 downregulation was found in Esophageal, Head/Neck, and Prostate Cancers, overexpression of Claudin-7 is found in many Ovarian Cancers and may also lead to increased tumor invasiveness.

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New Antibodies for Gall Bladder & Pancreatic Cancer Applications

New Antibodies for Head and Neck Cancer Applications

New Antibodies for Lymphoma Applications

cd5 anti-cd5 antibody immunohistochemisry ihc

CD5 (RM314), RMab

CD5 antibody expression is found in T-lymphocyte subsets and is modulated during cellular activation; however, it does not react with granulocytes or monocytes.

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SOX-11 (BSB-167), MMab

SOX-11 antibody nuclear expression is highly associated with both cyclin D1- positive and negative mantle cell lymphomas, with a stronger and more homogeneous Immunostain than cyclin D1.

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New Antibodies for GIST Applications

CD117 (RM359), RMab

CD117 antibody reacts with interstitial cells of Cajal, germ cells, bone marrow stem cells, melanocytes, breast epithelium and mast cells.

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