{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"CREB-Regulated Transcription Coactivator 3 (CRTC3) or TORC3, is a transcriptional coactivator for cAMP-responsive element-binding protein 1 (CREB1), which activates transcription through both consensus and variant CRE sites. It also regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. TORC3 works as a potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. It is a coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).\n TORC/CRTC proteins help regulate the cell’s response to c-AMP signaling, and are thus important activators in metabolic networks. Gain-of-function mutations can contribute to cancer cell survival and proliferation, such as in Melanoma, where TORC3/CTRC3 overexpression contributes to invasiveness and poorer prognosis. TORC3/CTRC3 is also involved in melanogenesis and the homeostasis of protecting against UV damage while allowing production of Vitamin D. Metabolic pathway regulation also contributes to the management of conditions such as Diabetes and cancer cachexia. CRTC-MAML2 gene fusions have been identified in 30-60% of Mucoepidermoid Carcinomas in the salivary glands, though no prognosis was found from fusion status."}]}]}