New Antibodies for Breast Cancer Applications

atm, anti-atm, Ataxia telangiectasia mutated

ATM (EP327), RMab

Mutations in the ATM gene lead to an increased risk of several cancer types, which include Leukemias, Lymphomas, Colorectal Cancer, Pancreatic Cancer and Adenocarcinoma of the Stomach.

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aurora b, anti-aurora b, aurora b kinase

Aurora B (RM278), RMab

Abnormal expression of Aurora B antibody has been found in many cancer types, such as Non-Small Cell Lung Carcinoma, Mesothelioma, Glioblastoma, Oral Cancer and Hepatocellular Carcinoma.

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CXCL12 / SDF-1 (BSB-165), MMab

Expression of CXCL12 (SDF-1) and CXCR4 in breast, pancreatic, esophageal, lung, prostate, and ovarian Cancers increases angiogenesis and is associated with poor prognosis, especially in the presence of HER2-neu.

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estrogen receotpr, anti-estrogen receptor, er, anti-er, er-alpha, anti-er-alpha, er alpha, anti-er alpha, estrogen receptor alpha

Estrogen Receptor (RM292), RMab

This ER antibody recognizes a protein of 67 kDa, which is identified as estrogen receptor alpha. The Bio SB Estrogen Receptor (ER), RMab, is available in concentrate and convenient tinto predilute formats to meet your laboratory needs.

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Ki-67 (RM360), RMab

The Ki-67 antibody is an excellent marker to determine the growth fraction of a given cell population. The fraction of Ki-67 positive tumor cells (the Ki-67 labeling index) is often correlated with the clinical course of cancer.

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PELP1 (RBT-PELP1), RMab

PELP1 expression was associated with poor outcome in non-luminal cancers and modified the prognostic effects of AR, suggesting the potential significance of NR co-regulator in prognostication.

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PTEN (RM265), RMab

PTEN is one of the most commonly lost tumor suppressors in human cancer; in fact, up to 70% of men with prostate cancer are estimated to have lost a copy of the PTEN gene at the time of diagnosis.

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TDP-43 / TARDBP (BSB-166), MMab

TDP-43 (TARDBP) antibody expression is associated with several neurodegenerative conditions amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) and metabolic regulation in cancer cells.

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New Antibodies for Lung Cancer Applications

brg-1, brg1, anti-brg-1, anti-brg1, smarca-4, anti-smarca-4, smarca4, anti-smarca4

BRG-1 / SMARCA4 (BSB-154), MMab

BRG-1 (or SMARCA4) antibody expression loss occurs in a portion of tested cancers types, including Breast, Colon, Head/Neck, Ovarian, Liver and Renal Cell Cancer. On the contrary, overexpression of BRG-1 was found in Breast, Colorectal, and Prostate Cancer, as well as Melanoma and Neuroblastoma.

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CD73 / NT5E (RM431), RMab

CD73 (NT5E) antibody overexpression was found to be associated with several types of human cancers including Bladder, Brain, Invasive Lobular Breast, Esophageal, Gastric, Pancreatic, Rectal mucinous, Renal Cell, Lung Large Cell, oral cavity Squamous Cell, Melanoma, and Lung Adenocarcinoma Cancers.

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insm-1, anti-insm1, anti insm1, anti-insm1, IA 1, IA1, insulinoma associated 1, insulinoma associated protein 1, INSM1, IA 1, IA1, insulinoma associated 1, insulinoma associated protein 1, Zinc finger protein IA 1

INSM1 (RBT-INSM1), RMab

INSM1 antibody is abundantly expressed in fetal neuroendocrine developmental tissues and expressed in normal adult neuroendocrine (NE) tissues (adrenal medulla, pineal gland, pituitary gland, gastrointestinal enterochromaffin cells, pancreatic islet cells, thyroid C cells) and developing neurons.

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Lamin-B1 (RBT-LMNB1), RMab

Lamin-B1 loss is associated with cellular senescence and a broad range of aging-related diseases such as cardiovascular diseases and cancers. Recent studies showed Lamin-B1 deficiency promotes Lung Cancer development and metastasis by epigenetic derepression of RET, as well as malignancy and poor prognosis in Gastric Cancer.

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Musashi 2 (RM422), RMab

Musashi 2 antibody can indicate the presence of stem cells in tumors of Colorectal, Lung, and Pancreatic Cancers, and in Glioblastoma, Leukemias, and xenografts, where it supports proliferation and prevents apoptosis.

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pan-TRK (RM423), RMab

NTRK gene fusions are also found in Brain primary tumors and metastases, Lung, Breast, Papillary Thyroid Carcinoma, Colorectal and Pancreatic cancer.

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SOX-2 (RM427), RMab

SOX-2 antibody is expressed in fetal brain and is used as a marker for multipotential neural stem cells. In tumors, SOX-2 expression is observed in teratoma of the central nervous system, melanoma, testicular germ cell tumor, cervical carcinoma, lung cancer, breast cancer with basal cell phenotype, and squamous cell carcinoma of the gastrointestinal tract.

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YAP1 (BSB-146), MMab

YAP1 antibody It is frequently overexpressed in Mammary carcinoma, Glioblastoma and Squamous Cell Carcinoma, Pancreatic, Oral, Cervical, Ovarian and Lung Cancers.

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New Antibodies for Neural and Neuroendocrine Cancer Applications

GAB1 / GRB2-Associated-Binding Protein 1 (BSB-155), MMab

Somatic mutations of the GAB1 gene have been detected in Breast and Colorectal Cancers and studies have shown that elevated expressions of GAB1 (GRB2-associated-binding protein 1) antibody have been associated with Breast Cancer metastasis by dissociating the polarity-associated partitioning defective (PAR) complex and promoting epithelial-to-mesenchymal transition.

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IDH1 R132H (RBT-IDH1), RMab

Mutation of IDH1 is implicated in metaphyseal chondromatosis with aciduria as well as diffused gliomas and a number of neoplasms such as acute myeloid leukemia, acute lymphocytic leukemia, myelofibrosis, intrahepatic cholangiocarcinoma, melanoma, chondroid tumors, and certain rare forms of colonic and prostate carcinomas.

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MGMT / AGAT (EP337), RMab

High MGMT (AGAT) antibody expression has been reported in Glioma, Myeloma, Melanoma, Colon and Pancreatic Cancers, where inhibition or down-regulation make alkylating drug treatments more effective.

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New Antibodies for SARS-CoV-2 and Cytokine Storm Syndrome IHC Applications

ace2 ace-2 anti-ace2 anti-ace-2 antibody immunohistochemistry ihc

ACE2 (BSB-135), MMab

ACE2 functions as the main receptor for the spike glycoprotein of human coronaviruses HCoV-NL63, SARS-CoV and SARS-CoV-2.

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cd147 anti-cd147 antibody immunohistochemistry ihc

CD147 (BSB-137), MMab

CD147 antibody has been found to be upregulated in cancer stem cells, resulting in increased metabolism through lactic acid export, increased production of hyaluronan, inhibiting apoptosis, and acting as a main upstream stimulator of matrix metalloproteinases.

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IFN-a (BSB-158), MMab

IFN-a strongly modulates innate and adaptive immune responses in the host by enhancing the proliferation, cytotoxicity and IFN-γ secretion of NK cells, as well as acting as a pyrogenic factor by altering the activity of thermosensitive neurons in the hypothalamus which causes fever.

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IFN-y (BSB-161), MMab

IFN-γ is used to treat Chronic Granulomatous Disease and Osteopetrosis, also has potential as cancer immunotherapy to improve survival in Bladder Carcinoma, Melanoma, and Ovarian Carcinoma.

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il-1a anti-il-1a il1a anti-il1a antibody immunohistochemistry ihc

IL-1a (BSB-138), MMab

IL-1a antibody is involved in cancer cell cross-talk and metastasis, and the secretion of cell growth, angiogenesis, and inflammation factors as a Damage-Associated Molecular Pattern.

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il1b il-1b anti-il1b anti-il-1b antibody immunohistochemistry ihc

IL-1b (BSB-139), MMab

IL-1b is produced by tumor-infiltrating myeloid cells, which then produce VEGF and other angiogenesis-related factors, promoting growth in multiple tumor types.

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il6 il-6 anti-il6 anti-il-6 antibody immunohistochemistry ihc

IL-6 (BSB-140), MMab

IL-6 antibody reactivity is often found in immune tissues, podocytes, mesangial cells, endothelial and epithelial cells.

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tmprss2 anti-tmprss2 antibody immunohistochemistry ihc

TMPRSS2 (BSB-136), MMab

TMPRSS2 antibody is expressed in the GI tract, stomach, kidney and in the lung epithelium, where it may cleave epithelial sodium channels.

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tnfa-ip2 tnfa ip2 tnfaip2 tnfa anti-tnfa antibody immunohistochemistry ihc

TNFa-IP2 (BSB-141), MMab

TNFa-IP2 antibody expression is found in epithelial cells, and immune cells exposed to Tumor Necrosis Factor alpha (TNFa), IL-1beta, LPS, interferon-y, Retinoic Acid, Latent Membrane Protein 1 (LMP1), and other pro-inflammatory cytokines.

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New Antibodies for Immunotherapy Applications

ICOS / CD278 (RM417), RMab

ICOS (CD278)antibody is a sensitive marker for identifying T cell Lymphomas of Follicular Helper T cell origin, especially certain patterns of Angioimmunoblastic T-cell lymphoma (AITL) and Peripheral T-cell lymphomas with T-follicular Helper Phenotype (PTCL-TFH).

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IFN-a (BSB-158), MMab

IFN-a strongly modulates innate and adaptive immune responses in the host by enhancing the proliferation, cytotoxicity and IFN-γ secretion of NK cells, as well as acting as a pyrogenic factor by altering the activity of thermosensitive neurons in the hypothalamus which causes fever.

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IFN-y (BSB-161), MMab

IFN-γ is used to treat Chronic Granulomatous Disease and Osteopetrosis, also has potential as cancer immunotherapy to improve survival in Bladder Carcinoma, Melanoma, and Ovarian Carcinoma.

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TIM-3 / HAVCR2 / CD366 (BSB-163), MMab

Co-expression of PD-1 and TIM-3 was correlated with AML progression. In follicular B-cell non-Hodgkin lymphoma, TIM-3 (HAVCR2/CD366) was expressed on nearly 35% of lymph node CD4+ and CD8+ T cells and could mediate T-cells exhaustion.

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Fast IHC Antibodies

New IHC Detection Kits

New MultiDetector Detection Kits

HPV MultiDetector HRP/AP Kit

The HPV MultiDetector HRP/AP Kit dual stain includes a cocktail of Ki67 and p16 antibodies to form a sensitive and specific test for significant cervical lesions or oral and oropharyngeal SCC.

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PIN MultiDetector HRP/AP Kit

The Prostate Intraepithelial Neoplasia (PIN) MultiDetector HRP/AP Kit is a Multiplex triple color IHC Kit designed to detect prostate cancer in situ in the prostate glands.

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New Tissue and Cell Line Microarrays

2-Tissue Human PIN TMA

The 2-tissue Human PIN TMA is an unstained ready-to-use microscope slide consisting of 2 sections of normal human formalin-fixed paraffin-embedded Myometrium (negative control) and Prostate Cancer (positive for CK 34BE12, AMACR and p63).

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3-Core ROS1 Cell Line Microarray

The 3 Core ROS1 Cell Line Microarray is an unstained ready-to-use microscope slide consisting of 3 – 2 mm cores of normal human formalin-fixed paraffin-embedded cell lines.

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4-Core MMR Cell Line Microarray

The 4 Core MMR Cell Line Microarray is an unstained ready-to-use microscope slide consisting of 4 – 1 mm cores of knockout mutations of the individual mistmatch repair genes MLH1, MSH2, MSH6 and PMS2.

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New IHC Ancillaries

Fast ChromoProtector

The Fast ChromoProtector is for use in histological, immunohistochemical and in situ hybridization staining procedures to preserve stains before the permanent mounting of tissues or cell preparations.

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Pink Hematoxylin Counterstainer

Pink Hematoxylin Counterstainer provides a nuclear pink counterstain for Immunocytochemical, Immunohistochemical and CISH procedures. It is an acidic stain that will adhere to any proteins with basic characteristics and yields a contrasting color from that of the chromogen in an immunohistochemical reaction. Pink Hematoxylin Counterstainer also enables for more distinct viewing of the morphological characteristics of cells or tissue sections

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