Pancreatic Tumors Return to Top | ||||||||||||||||
| CARCINOMAS | Synaptophysin | Chromogranin_A | Insulin | Glucagon | Gastrin | Somatostatin | MUC4 | CD56 | B-Catenin | PGP 9.5 | CK19 | CA19-9 | bcl-10 | E-Cadherin | CD10 | Maspin |
| Pancreatic Adenocarcinoma | – | – | – | – | – | – | + | – | – | – | + | + | – | +/- | + | |
| Neuroendocrine Tumor | + | + | +/- | +/- | +/- | +/- | – | + | + | + | +/- | +/- | – | – | – | – |
| Solid Pseudopapillary | + | – | – | – | – | + | + | – | – | – | – | – | + | – | ||
| Pancreatic Ductal Carcinoma | – | – | – | – | – | – | +/- | – | + | – | +/- | +/- | + | |||
| Acinic Cell Carcinoma | – | – | – | – | – | – | + | – | + | -/+ | + | + | +/- | – | ||
| Pancreatoblastoma | – | + | – | – | – | – | – | + | + | – | – | – | + | – | – | + |
| Benign Pancreas | + | + | + | + | – | + | – | – | + | – | – | – | – | – | – | |
Brain CNS Tumors Return to Top | |||||||||||
| CARCINOMAS | GFAP | Neurofilament | Synaptophysin | S-100 | CK Cocktail | PR | EMA | Vimentin | NGFR | INI-1 | SOX2 |
| Astrocytoma | +/- | – | – | + | – | – | – | + | + | + | + |
| Glioblastoma | + | – | – | + | – | – | – | + | – | + | + |
| Oligodendroglioma | – | – | – | + | – | – | – | + | – | + | + |
| Ependymoma | +/- | – | – | + | – | – | – | -/+ | + | + | + |
| Choroid Plexus Carcinoma | -/+ | – | + | + | + | – | – | – | + | ||
| Central Neurocytoma | -/+ | – | +/- | – | – | – | – | – | + | + | + |
| Neuroblastoma | +/- | + | +/- | +/- | – | – | – | – | + | + | – |
| Pineocytoma | -/+ | – | + | + | – | – | – | – | + | – | |
| Meningioma | – | – | – | – | – | + | + | + | – | + | – |
| Schwannoma | + | – | – | + | -/+ | – | – | + | + | – | |
| Rhabdoid Tumors | – | +/- | +/- | + | + | + | – | ||||
| Metastatic Carcinoma | – | – | – | – | + | -/+ | + | -/+ | – | – | |
Kidney Renal Epithelial Tumors Return to Top | |||||||||||
| CARCINOMAS | RCC | CD10 | PAX-2 | Vimentin | Ksp-Cadherin | Parvalbumin | CD117 | Ep-CAM | Caveolin-1 | PAX-8 | pVHL |
| Clear Cell Renal Cell Carcinoma | + | + | + | + | – | – | – | – | + | + | + |
| Chromophobe RCC | – | – | – | – | + | + | + | + | + | + | + |
| Oncocytoma | – | – | – | – | + | + | + | – | +/- | + | + |
Breast Carcinomas Return to Top | |||||||||
| CARCINOMAS | CK7 | CK20 | ER/PR | CD44 | CA15-3 | CA19-9 | p63 | CK5 | CD117 |
| Infiltrating Ductal Carcinoma | + | – | + | + | + | – | – | – | – |
| Adenoid Cystic Carcinoma | + | – | – | – | + | + | + | + | + |
Breast vs Lung vs Prostate Carcinomas Return to Top | |||||||
| CARCINOMAS | GCDFP-15 | Mammaglobin | CA15-3 | Caveolin-1 | PSA | TTF-1 | Napsin A |
| Breast Carcinoma | + | + | + | + | – | – | – |
| Lung Carcinoma | – | – | – | – | – | + | + |
| Prostate Carcinoma | – | – | – | +/- | + | – | – |
Differential Diagnosis of Parathyroid Tumors Return to Top | |||||||
| CARCINOMAS | Chromogranin A | Synaptophysin | PTH | S-100 | TTF-1 | Calcitonin | PAX-8 |
| Parathyroid Tumors | + | + | + | – | – | – | – |
| Follicular Cell Tumors | – | – | – | +/- | + | – | + |
| Medullary Thyroid Carcinoma | + | + | – | – | + | + | + |
Sex Cord Stromal Tumors Return to Top | |||||||
| CARCINOMAS | Calretinin | Inhibin | CD99 | CK7 | EMA | Vimentin | MART-1 |
| Granulosa Cell Tumors | + | + | + | – | – | + | + |
| Sertoli-Leydig Cell Tumors | + | + | -/+ | + | – | + | + |
| Gynandroblastoma | + | + | |||||
| Gonadoblastomas | + | + | + | – | – | + | – |
Uterus: Trophoblastic Cells Return to Top | ||||||
| 1st Trimester | 2nd Trimester | 3rd Trimester | ||||
| Trophoblastic Cells | hCG | hPL | hCG | hPL | hCG | hPL |
| Cytotrophoblast | – | – | – | – | – | – |
| Intermediate Trophoblast | 1-24% | 25-49% | -/+ | 50-74% | 1-24% | 1-49% |
| Syncytiotrophoblast | 75% | 1-24% | 25-49% | 50-74% | 1-24% | 75% |
Uterus : Trophoblastic Proliferations Return to Top | ||||||
| Trophoblastic Proliferations | p57 | hCG | PLAP | hPL | CK Cocktail | Vimentin |
| Partial Mole | + | weak, diffuse | + | weak, diffuse | strong, diffuse | – |
| Complete Mole | – | strong, diffuse | weak, focal | weak, focal | strong, diffuse | – |
| Choriocarcinoma | – | strong, diffuse | weak, focal | weak, focal | strong, diffuse | – |
| Placental Site Tumor | strong, focal | strong, diffuse | strong, diffuse | strong, diffuse | strong, diffuse | |
Skin: Adnexal Tumors Return to Top | ||||||
| CARCINOMAS | CK7 | CK20 | S-100 | EMA | GCDFP-15 | CD15 |
| Merkel Cell Carcinoma | – | + | – | + | – | – |
| Sebaceous Tumor | + | – | – | – | – | + |
| Apocrine Tumor | – | – | +/- | + | +/- | |
| Eccrine Tumor | – | + | + | – | – | |
Breast Lesion Return to Top | ||||||
| Breast Lesion | GCDFP-15 | Mammaglobin | B-Catenin | E-Cadherin | CK, 34bE12 | p120 |
| Lobular | + | + | – | – | + | + (cytoplasmic) |
| Ductal | + | + | + (membranous) | + | – | + (membranous) |
Meningiomas from Histologic Mimics Return to Top | |||||
| Meningiomas | Claudin 1 | EMA | S-100 | CD34 | GFAP |
| Meningothelial Meningioma | + | + | – | – | – |
| Atypical Meningioma | + | + | – | + | – |
| Fibrous Meningioma | – | + | + | – | – |
| Solitary Fibrous Tumor | – | – | – | + | – |
| Meningeal Hemangiopericytoma | – | – | – | + | – |
| Schwannoma | +/- | – | + | – | + |
Renal Cell Carcinoma vs Hemangioblastoma Return to Top | |||||
| Carcinomas | D2-40 | FLI-1 | CD31 | CK Cocktail | CD10 |
| Metastatic Renal Cell Carcinoma | – | – | – | + | + |
| Hemangioblastoma | + | + | + | – | – |
Ovarian Carcinomas Return to Top | |||||
| Carcinomas | PAX-8 | WT1 | CA-125 | CEA | pVHL |
| Ovarian Carcinoma, Serous | + | + | + | + | – |
| Ovarian Carcinoma, Mucinous | – | – | – | – | – |
| Ovarian Endometrioid Carcinoma | + | – | + | – | – |
| Ovarian Clear Cell Carcinoma | + | – | + | – | + |
Skin: Pagetoid Tumors Return to Top | |||||
| Tumors | CK, LMW | CK, HMW | S-100 | CEA | Vimentin |
| Melanoma | – | – | + | – | + |
| Paget’s Disease | + | – | -/+ | + | – |
| Bowen’s Disease | + | + | – | – | – |
Skin : Basal vs Squamous Cell Carcinoma Return to Top | ||||
| Carcinomas | CK Cocktail | Ep-CAM | EMA | bcl-2 |
| Basal Cell Carcinoma | + | + | – | + |
| Squamous Cell Carcinoma | + | – | + | – |
Perineurioma vs Neurofibroma Return to Top | ||||
| Tumors | Claudin 1 | EMA | S-100 | GLUT1 |
| Perineurioma | + | + | – | + |
| Neurofibroma | + | + | – | – |
Breast Carcinoma in situ vs Infiltrating Breast Carcinoma Return to Top | ||||
| Carcinomas | Calponin | SM Myosin | p63 | |
| Breast Carcinoma in-situ | + | + | + | |
| Infiltrating Breast Carcinoma | – | – | – | |
Pancreas vs Pancreatic Adenocarcinoma Return to Top | ||||
| Tumors | pVHL | S-100 | Maspin | |
| Pancreas | + | – | – | |
| Pancreatic Intraepithelial Neoplasia | – | + | + | |
| Pancreatic Adenocarcinoma | – | + | + | |