IHC of SATB2 on an FFPE Colon Adenocarcinoma tissue
| Intended Use | SOX-11 (BSB-184), mouse monoclonal antibody, is a primary antibody intended for laboratory use by trained laboratory personnel in an immunohistochemical (IHC) assay to qualitatively identify the SOX-11 protein by light microscopy in normal and/or pathological formalin-fixed, paraffin-embedded (FFPE) human tissue. The clinical interpretation of any staining or its absence should be performed by a qualified pathologist and complemented by morphological studies using proper controls and evaluated within the context of the patient’s clinical history and other diagnostic tests.
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| Summary and Explanation | Transcription factor SOX-11 is a member of the group C SOX (SRY-related HMG-box) transcription factor family involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may function in the developing nervous system and play a role in tumorigenesis and adult neurogenesis. SOX-11 is normally expressed in the developing human central nervous system, Medulloblastoma, and Glioma. Anti-SOX-11 nuclear protein expression is highly associated with both Cyclin D1-positive and negative Mantle Cell Lymphomas, with a stronger and more homogeneous immunohistochemistry staining than cyclin D1. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Mouse Monoclonal | Clone | BSB-184 | |||||||||||||||||||||||||||||||||
| Isotype | IgG1 | Reactivity | Human | |||||||||||||||||||||||||||||||||
| Localization | Nuclear | |||||||||||||||||||||||||||||||||||
| Presentation | This antibody is derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide. | |||||||||||||||||||||||||||||||||||
| Availability |
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
