IHC of MSH6 on an FFPE Colon Adenocarcinoma tissue
| Intended Use | MSH6 (RBT-MSH6), rabbit monoclonal antibody, is a primary antibody intended for laboratory use by trained laboratory personnel in an immunohistochemical (IHC) assay to qualitatively identify the MSH6 protein by light microscopy in normal and/or pathological formalin-fixed, paraffin-embedded (FFPE) human tissue. The clinical interpretation of any staining or its absence should be performed by a qualified pathologist and complemented by morphological studies using proper controls and evaluated within the context of the patient’s clinical history and other diagnostic tests. | |||||||||||||||||||||||||||||||||||
| Summary and Explanation | MSH6, also known as mutS homolog 6, is a gene commonly associated with Hereditary Non-Polyposis Colorectal Cancer (HNPCC). HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset Colorectal Carcinoma and extra-colonic cancers of the gastrointestinal, urological and female reproductive tracts. HNPCC is reported to be the most common form of inherited Colorectal Cancer in the western world. MSH6 is a mismatch repair gene which is deficient in a high proportion of patients with microsatellite instability (MSI-H). The anti-MSH6 antibody is useful in screening patients and families for HNPCC. Colon cancers that are microsatellite-unstable have a better prognosis than their microsatellite-stable counterpart. | |||||||||||||||||||||||||||||||||||
| Antibody Type | Rabbit Monoclonal | Clone | RBT-MSH6 | |||||||||||||||||||||||||||||||||
| Isotype | IgG | Reactivity | Human | |||||||||||||||||||||||||||||||||
| Localization | Nuclear | |||||||||||||||||||||||||||||||||||
| Presentation | This antibody is derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide. | |||||||||||||||||||||||||||||||||||
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| Note: For concentrated antibodies, please centrifuge prior to use to ensure recovery of all product. | ||||||||||||||||||||||||||||||||||||
