MUC1 is a large cell, surface-mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. MUC1 antibody expression is seen in lactating mammary glands and overexpressed in more than 90% Breast Carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands.


In a high proportion of patients with microsatellite instability (MSI-H), the MLH1 protein is typically deficient. This protein deficiency is linked to the autosomaldominant condition of Hereditary Non-Polyposis Colon Cancer. The anti – MLH1 antibody is useful in screening patients and families for this condition. The Bio SB MLH1, MMab, is available in concentrate and convenient tinto predilute formats to meet your laboratory needs.

PolyDetector HRP Black

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