PiT-1 (BSB-182), MMab

PiT-1 (BSB-182), mouse monoclonal antibody, is a primary antibody intended for laboratory use by trained laboratory personnel in an immunohistochemical (IHC) assay to qualitatively identify the PiT-1 protein by light microscopy in normal and/or pathological formalin-fixed, paraffin-embedded (FFPE) human tissue.

The clinical interpretation of any staining or its absence should be performed by a qualified pathologist and complemented by morphological studies using proper controls and evaluated within the context of the patient’s clinical history and other diagnostic tests.

POU1F1 is a tissue specific transcription factor that regulates gene expression, particularly in somatotrophs, lactotrophs, and thyrotrophs, found in the developing anterior pituitary. The POU class 1 homeobox 1 transcription factor (POU1F1, also known as Pit-1) was originally detected in the pituitary gland and is expressed in the mammary gland; it can regulate cell differentiation and is an activator for pituitary gene transcription during organogenesis. 

Pit-1 deregulation induces a malignant phenotype in breast cancer cells associated with tumor growth and metastasis. One study determined that Pit-1 was detected in human placenta, human breast adenocarcinoma cell line, and hematopoietic and lymphoid tissues. Moreover, abnormal expression of Pit-1 in these tissues was reported to be associated with tumor progression. In another study, an increased expression level of Pit-1 was found in exponentially growing human myeloid leukemic cells, and the level was specifically associated with cell proliferation.