{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"PRAME (Preferentially Expressed Antigen in Melanoma) is a protein that typically plays a role in embryonic development and tissue differentiation, where it likely contributes to regulating gene expression and cellular processes. PRAME is normally not expressed or is expressed at very low levels in most adult tissues, but it is highly expressed in various cancer types. PRAME is believed to play a role in promoting cell proliferation, inhibiting cell death (apoptosis), and potentially aiding in immune evasion by cancer cells. During diagnosis of skin cancer, immunohistochemical analysis for PRAME expression may be useful to support a suspected diagnosis or assess the margins of melanoma, but its expression in benign skin conditions can represent a challenge. PRAME expression has also been observed in other cancers, including subsets of leukemia, synovial sarcoma, neuroblastoma, some subtypes of breast cancer, and some cases of non-small cell lung cancer."}]}]}