{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"PiT-1 (also known as POU1F1, POU class 1 homeobox 1 transcription factor) was originally detected in the pituitary gland. PiT-1 regulates cell differentiation and is an activator for pituitary gene transcription during organogenesis. PiT-1 is important in the classification of pituitary neuroendocrine tumors. Pit-1 is also detected in other tissues, such as human placenta, breast carcinoma, hematopoietic and lymphoid tissues. Abnormal expression of PiT-1 is associated with tumor progression according to literature."}]}]}