{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Enhancer of zeste homolog 2 (EZH2) is an enzymatic catalytic subunit of polycomb repressive complex 2 (PRC2) which regulates gene expression by methylating lysine 27 on histone H3 and lysine 299 on GATA4. EZH2 is often found to be overexpressed or mutated in various cancers. EZH2 dysregulation can lead to increased cell survival and cancer development when apoptosis inducing genes are silenced. EZH2 also regulates naïve T cell function, impacting their ability to proliferate, differentiate, and survive."}]}]}