{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Yes-associated protein 1 (YAP1) is a regulatory protein that binds the Src family tyrosine kinase (YES), promotes transcriptional activation of cyclin E and inhibition of caspase-induced apoptosis. YAP1 is found in the cytoplasm, though transported into the nucleus to perform its roles in proliferation and assist in tissue repair and growth. YAP1 is essential for cancer growth, contributing to stem-cell-like features of proliferation and metastasis and inducing these features in neighboring cells. YAP1 may be upregulated or have higher nuclear localization in more malignant and metastatic tumors. YAP1 has been found to be expressed in fetal and adult brain regions known to harbor neural progenitor cells as well as the nuclei of brain tumors."}]}]}