{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Varicella Zoster Virus (VZV) is a member of the human herpes virus family and causes two distinct clinical manifestations: chickenpox and shingles. VZV particles are approximately 80–120 nm in diameter. Linear VZV genomes are packaged into an icosahedral nucleocapsid core that is formed from proteins encoded by orf20, orf21, orf23, orf33, orf40 and orf41. Capsids are surrounded by a tegument layer, which is a less well-defined structure that is made up of proteins with known or predicted regulatory functions, including the immediate-early (IE) viral transactivating factors that are encoded by orf4, orf62 and orf63, those that are encoded by the orf9–orf12 gene cluster, the two viral kinases ORF47 and ORF66, and others. The outer virion component is a lipid membrane envelope that is derived from cellular membranes with incorporated viral glycoproteins, including gB/gH–gL, which form the minimal fusion complex."}]}]}