{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Tumor-associated calcium signal transducer 2 (Trop-2), also known as epithelial glycoprotein-1 antigen (EGP-1), is a protein that in humans is encoded by the TACSTD2 gene. This transmembrane glycoprotein functions in a variety of cell signaling pathways and was first elucidated as a transducer of an intracellular calcium signal. Trop-2 expression has been demonstrated to depend on a large variety of transcription factors. Trop-2 is involved in several cell signaling pathways, of which many are associated with tumorigenesis. Increased Trop-2 expression has been associated with poor overall and disease-free survival outcomes across several solid tumors. Given Trop-2’s expression pattern and associated poor prognostic outcomes, Trop-2 may be a possible therapeutic target."}]}]}