{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Transactive Response DNA binding protein 43 (TPD-43 or TARDBP) is an RNA and DNA binding protein in the heterogeneous nuclear ribonucleoprotein (hnRNP) family, where it regulates RNA associated with glucose and lipid metabolism. TDP-43/TARDBP plays a crucial role in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) as protein aggregates of TDP-43 are found in these diseases. TDP-43 can influence cancer cell behavior, impacting processes like cell proliferation, apoptosis, and metastasis. It can also affect the tumor microenvironment, angiogenesis, and immune responses. TDP-43 interacts with various non-coding RNAs (ncRNAs), including miRNAs and long non-coding RNAs (IncRNAs) (lncRNAs), which also play roles in cancer development and progression."}]}]}