{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"T-cell leukemia/lymphoma protein 1 (TCL1, TCL1A, p14TCL1) is involved in T-cell prolymphocytic leukemia (T-PLL) and is normally found in the nucleus and cytoplasm of lymphoid lineage cells during early embryogenesis. Chromosomal translocations may lead to overexpression of TCL1, resulting in T-cell leukemia and B-cell lymphoma. TCL1 is expressed in more differentiated B-cells, under both reactive and neoplastic conditions, in antigen committed B-cells and in germinal center B-cells. TCL1 is down-regulated in the latest stage of B-cell differentiation. According to literature, TCL1 is overexpressed in different types of B-cell lymphomas, such as Burkitt lymphoma and AIDS-related non-Hodgkin’s lymphoma."}]}]}