{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Sry-related high-mobility group box (SOX) gene family contains more than 20 transcription factors. SOX-9, along with SOX-8 and SOX-10 share at least 70% identity and comprise the SOXE group. SOX-9 is required for development, differentiation, and lineage commitment in various tissues. During embryogenesis, SOX-9 is expressed in the cartilage, neural crest, kidney, and pancreas. SOX-9 is crucial for chondrocyte differentiation and regulates transcription of the anti-Müllerian hormone (AMH) gene, as mutations in SOX-9 causes campomelic dysplasia and autosomal sex reversal. SOX-9 also exhibits several pro-oncogenic properties, including the ability to promote proliferation, inhibit senescence, and collaborate with other oncogenes in neoplastic transformation. SOX9 has been found to be upregulated in several tumor types, such as lung adenocarcinoma, breast carcinoma, colorectal cancer, prostate cancer, and pancreatic ductal adenocarcinoma."}]}]}