{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Sry-related high-mobility group box (SOX) gene family contains more than 20 transcription factors. SOX-11, along with SOX-4 and SOX-12 are transcription factors belonging to the SOXC family. SOXC members can compete with each other for binding to target genes and influencing their activity. SOX-11 is essential for neuronal development, regulation of progenitor and stem cells, and skeletal development. SOX-11 dysregulation occurs in various types of cancers as well as neurodevelopmental disorders and osteoarthritis. SOX-11 expression is seen in the developing human central nervous system, medulloblastoma, and glioma. According to literature, SOX-11 nuclear protein expression is highly associated with both cyclin D1- positive and negative mantle cell lymphomas. Absence of SOX-11 expression in mantle cell lymphoma may be a characteristic of indolent mantle cell lymphoma."}]}]}