{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"The Severe Acute Respiratory Syndrome 2 virus (SARS-CoV-2) is a betacoronavirus first isolated in Wuhan, China, in late 2019. The virus has a 29.8 kbp genome, encoding the membrane, envelope, nucleocapsid, and spike glycoprotein. The spike proteins are cleaved by TMPRSS2 serine protease, then the Receptor Binding Domain of the spike protein binds with ACE2 or CD147 to enter the cell. The SARS-2 virus has been shown to infect the tracheal and lung epithelium, gastrointestinal tract, and olfactory neuron, brain, bone marrow and possibly other organs. Cough, fever, and trouble breathing are the main symptoms, although gastrointestinal distress, fatigue, and neurological distress are also common."}]}]}