{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Myeloid Related Protein 8 (MRP8), also known as S100A8, is a calcium binding protein that belongs to the S100 family. By a Ca2+ dependent manner, S100A8/A9 forms calprotectin, a heterodimeric inflammatory mediator of inflammation found in the cytoplasm of neutrophils and on the membrane of monocytes. S100A8 is expressed during myeloid differentiation and chronic inflammations, and expressed constitutively or induced in epithelial cells during dermatose. S100A8 is expressed in cells with myeloid origin, including granulocytes, monocytes and macrophages, and it is observed in blood granulocytes and monocytes. S100A8 is also expressed in infiltrate macrophages during inflammatory reactions, but not in normal tissue macrophages. According to literature S100A8 positivity is also observed in various cancers and has been linked to cancer associated inflammation."}]}]}