{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Prostatic specific acid phosphatase (PSAP) is an enzyme expressed in the glandular epithelium of the normal and neoplastic prostate. It catalyzes the hydrolysis of various phosphate monoesters. PSAP may be found in increased amounts in men who have prostate cancer or other diseases. The highest levels of acid phosphatase are found in metastasized prostate cancer. Diseases of the bone, such as Paget’s disease or hyperparathyroidism, diseases of blood cells, (such as sickle-cell disease), multiple myeloma or lysosomal storage diseases, (such as Gaucher’s disease), will show moderately increased levels. Certain medications can cause temporary increases or decreases in acid phosphatase levels. Manipulation of the prostate gland through massage, biopsy or rectal exam before a test may increase the levels of PSAP."}]}]}