{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Proline-, glutamic acid- and leucine-rich protein 1 (PELP1), also known as HMX3 protein, is a transcription factor that plays a role in various cellular processes, including cell growth, differentiation, and cancer development. PELP1 is mainly known as a coactivator for estrogen receptor activity, where it participates in complexes that facilitate transcription according to ER-mediated signals. PELP1 interacts with a variety of signaling proto-oncogenes such as Src, HER2, and EGFR, which are known to contribute to tumor formation, and with hormonal pathways that can contribute to hormonal therapy resistance. The expression of PELP1 is deregulated in a variety of hormone-centered cancers."}]}]}