{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Paired box protein 7 (PAX-7) is a transcription factor involved in developmental pathways in neural tube and mesencephalon formation, muscle cell development, and oxidative stress sensitivity. PAX-7 regulates neural cell adhesion molecules and is expressed in proliferating myoblasts, but it is down-regulated after playing its role in cell differentiation toward muscle-derived specification. PAX-7 is restricted to muscle satellite and myogenic precursor cells in adults. PAX-7 is encoded by a gene on locus 1p36, which can translocate with forkhead in rhabdomyosarcoma gene (FKHR or FOXO1) on chromosome 13. The fusion PAX7-FKHR protein is frequently seen in alveolar rhabdomyosarcoma. According to literature, PAX-7 is also expressed in Ewing sarcoma and synovial sarcoma."}]}]}