{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Parafibromin, also known as cell division cycle 73 (CDC73 or HRPT2), is a component of the RNA polymerase II-associated factor 1 complex (PAF1C), which is involved in regulating gene expression by coordinating transcriptional elongation and histone modification. Parafibromin interacts with other subunits of PAF1C to facilitate the recruitment of histone-modifying enzymes and chromatin remodeling factors, thereby regulating the transcriptional activity of target genes involved in cell proliferation, differentiation, and apoptosis. Mutations in the CDC73 gene are associated with hyperparathyroidism-jaw tumor syndrome (HPT-JT) and parathyroid carcinomas."}]}]}