{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Tumor protein 53 (p53 or Tp53) is a transcription factor that regulates the cell cycle and functions as a tumor suppressor. p53 has been described as ”the guardian of the genome”, referring to its role in conserving genetic stability by preventing genome mutation. p53 has many anti-cancer mechanisms. It can activate DNA repair proteins when DNA sustains damage; it can also hold the cell cycle at the G1/S regulation point on DNA damage recognition. It can initiate apoptosis, programmed cell death if DNA damage proves to be irreparable. p53 is central to many of the cell’s anti-cancer mechanisms by induce growth arrest, apoptosis and cell senescence. Mutations involving p53 have been found in a wide variety of malignant tumors."}]}]}