{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"p27 (p27Kip1 or CDKN1B) is a cell cycle regulatory mitotic inhibitor of cyclin-dependent kinase (CDKI). p27 functions as a candidate-tumor suppressor, and has been proposed to function as a possible mediator of transforming growth factor beta (TGF-ꞵ) induced G1 arrest. p27 is up-regulated in response to antimitogenic stimuli, and the binding of p27 to cyclin/Cdk complexes such as cyclin D1/Cdk4 causes cellular arrest. According to literature, low p27 expression has been associated with unfavorable prognosis in several cancers."}]}]}