{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"p120 catenin, also known as CTNND1 is a member of the armadillo protein family, which has functions in cell adhesion and signal transduction. The association of catenins to the cytoplasmic domain of cadherins produces a complex which is linked to the actin filament network, important for maintaining cell-cell adhesion and preventing cadherins internalization. According to literature, cytoplasmic accumulation of p120 catenin has been observed in lung cancer, pancreatic cancer, gastric cancer and colon cancers and is associated with poor prognosis in colon cancer patients."}]}]}