{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"OX-40 also known as CD134 and tumor necrosis factor receptor superfamily member 4 (TNFRSF4), is a member of the TNFR-superfamily of receptors. OX-40 is expressed on activated CD4 and CD8 T cells as well as a number of other lymphoid and non-lymphoid cells. OX-40 and its binding partner, OX40L (CD252), generate costimulatory signals to a conventional T cell to promote division and survival, augmenting the clonal expansion of effector T cells and memory T cells. OX-40 and OX-40L also regulate cytokine production from T cells, antigen-presenting cells, NK cells, and NKT cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX-40/OX-40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases."}]}]}