{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Octamer-binding transcription factor 4 (OCT-4) also known as POU domain, class 5, transcription factor 1 (POU5F1) is a homeodomain transcription factor of the POU family. This protein is critically involved in maintaining the pluripotency and self-renewal of embryonic stem cells. OCT-4 is expressed in undifferentiated pluripotent cells, germ cells in ovaries and testes. Expression of the OCT-4 is potentially correlated with tumorigenesis and can affect some aspects of tumor behavior such as tumor recurrence or resistance to therapies. According to literature, OCT-4 is consistently detected in carcinoma in situ/gonadoblastoma, seminomas, germinoma, dysgerminoma, and embryonal carcinoma."}]}]}