{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Neurofilaments are the type IV family of intermediate filaments that are found in high concentrations along the axons of vertebrate neurons. It plays a crucial role in the maintenance of axonal structure, regulation of axon caliber, and facilitation of nerve conduction. Neurofilament expression is important in the studies of neuronal injury and neurodegenerative disease. Neurofilament is also expressed in a number of neural, neuroendocrine and endocrine tumors."}]}]}