{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"The S-methyl-5"},{"type":"text","value":"'"},{"type":"text","value":"-thioadenosine phosphorylase (MTAP) is an enzyme involved in the breakdown of S-methyl-5"},{"type":"text","value":"'"},{"type":"text","value":"-thioadenosine (MTA), a byproduct of polyamine synthesis. This allows the salvaged adenine and methionine to be reused in many pathways affecting cell proliferation, signaling, and apoptosis. The MTAP gene, located at 9p12.3, is co-deleted with CDKN2A gene (encodes p16 tumor-suppressor) in several types of cancer. MTAP deficiency leads to accumulation of MTA and potentially impacting cancer cell behavior."}]}]}