{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Lamin-B1 is an intermediate filament protein that in humans is encoded by the gene LMNB1. B-type lamin along with A-type lamin line the inner surface of the nuclear envelope and form a dynamic structure that is disassembled and reassembled each time a cell enters mitosis. Lamin-B1 plays a central role in chromatin organization, gene positioning, DNA replication and repair, cell cycle progression, stress responses, proliferation and differentiation."}]}]}