{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Islet-1, Insulin gene enhancer protein ISL-1, is a protein that in humans is encoded by the ISL1 gene. This gene encodes a transcription factor containing two N-terminal LIM domains and one C-terminal homeo domain. The encoded protein plays an important role in the embryogenesis of pancreatic islets of Langerhans. ISL1 has also been shown to interact with estrogen receptor alpha."}]}]}