{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"INI1 (Integrase Interactor 1), also known as SMARCB1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1) is a core subunit of the ATP-dependent SWI/SNF chromatin remodeling complex, which regulates gene accessibility by altering nucleosome positioning and histone modifications. INI1 acts as a scaffold protein that facilitates the assembly and function of the SWI/SNF complex, allowing it to bind to specific DNA sequences and remodel chromatin structure. INI-1 is often mutated or deleted in malignant rhabdoid tumors. Two isoforms of INI-1, that differ by the variable inclusion of amino acids, potentially are produced by differential RNA splicing."}]}]}