{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Immunoglobulin A (IgA) is the main immunoglobulin in mucous secretions, including tears, saliva, and colostrum, as well as respiratory, intestinal, prostatic, and vaginal secretions. It is also found in small amounts in blood. Because it is resistant to degradation by enzymes, secretory IgA provides protection against microbes proliferating in body secretions, especially those of the digestive and respiratory tracts. IgA nephropathy characterized by IgA deposits is an inflammation of the kidneys caused by systemic lupus erythematosus. According to literature, confirming the presence of IgA through IHC can be important in the diagnosis of certain diseases that affect the immune system and produce abnormal immunoglobulins."}]}]}