{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"High-mobility group AT-hook 2 (HMGA2) belongs to the architectural transcription factor HMGA family and is encoded by the HMGA2 gene. HMGA2 plays a role in chromosomal organization and transcriptional regulation. HMGA2 has three basic DNA-binding domains (AT-hooks) that bind to AT rich regions of nuclear DNA and alter the structure of DNA to promote the assembly of protein complexes that regulate transcription. With few exceptions, HMGA2 is expressed in humans only during early development, and is reduced to undetectable levels of transcription in adult tissues. Studies show elevated expression of HMGA2 is found in a variety of human cancers, correlates with metastasis and poor prognosis for patients."}]}]}