{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Sialylated protein HEG homolog 1 or Heart development protein with EGF like domains 1 (HEG1) is a novel calcium binding receptor protein involved in the Cerebral Cavernous Malformations (CCM) pathway and plays a regulatory role in heart and vessel formation by stabilizing endothelial cell junctions. HEG1 is a heavily glycosylated protein that participates in endothelial cell associations that develop the vascular system, and therefore plays a role in angiogenesis and the microenvironment of cellular adhesion. The exact role of HEG1 in hepatocellular carcinoma is unclear, however, studies have shown HEG1 indicates poor prognosis and plays important roles in hepatocellular carcinoma invasion, metastasis, and epithelial mesenchymal transition by activating Wnt/β-catenin signaling. According to literature, HEG1 has also been found to be a useful biomarker for malignant mesothelioma in pleural (lung) and peritoneal (abdominal) membranes, and several other rare locations, where it supports the survival and proliferation of mesothelioma cells."}]}]}