{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Factor H or Complement Factor H (CFH), is the major soluble inhibitor of complement, where its binding to self markers (i.e. particular glycan structures) prevents complement activation and amplification on host surfaces. Mutations and polymorphisms that affect recognition of self markers by Factor H are associated with diseases of complement dysregulation, such as age-related macular degeneration and atypical hemolytic uremic syndrome. In addition, pathogens and cancer cells can hijack Factor H to evade the immune response. Several studies have also suggested the importance of Factor H in the protection of tumor cells against complement activation."}]}]}