{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Cadherins are a class of transmembrane proteins. They play an important role in cell adhesion by ensuring cells within tissues are bound together. E-Cadherin is an adhesion protein that is expressed in cells of epithelial lineage. It stains positively in glandular epithelium as well as Adenocarcinomas of the lung and G.I. tract, and ovary. According to literature, loss of E-Cadherin function or expression has been implicated in cancer progression and metastasis. E-Cadherin downregulation decreases the strength of cellular adhesion within a tissue, resulting in an increase in cellular motility. This may then allow cancer cells to cross the basement membrane and invade surrounding tissues."}]}]}