{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Cytokeratins are intermediate-filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue. There are two types of cytokeratins: acidic type I cytokeratins and basic or neutral type II cytokeratins. Cytokeratins are usually found in pairs comprising a type I cytokeratin and a type II cytokeratin. Expression of these cytokeratins is frequently organ or tissue specific. Cytokeratin MNF116 is a broad-spectrum anti-cytokeratin reacting with intermediate and low-molecular-weight keratins, ranging from 40 through 58 kDa, corresponding to cytokeratin 5, 6, 8, 17 and 19. It shows a broad pattern of reactivity with human epithelial tissues from simple glandular epithelium to stratified squamous epithelia, like epidermis, mammary gland ducts, and tracheal epithelium."}]}]}