{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Cytokeratins are intermediate-filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue. There are two types of cytokeratins: acidic type I cytokeratins and basic or neutral type II cytokeratins. Cytokeratins are usually found in pairs comprising a type I cytokeratin and a type II cytokeratin. Expression of these cytokeratins is frequently organ or tissue specific and cytokeratin marker is used to study the distribution of keratin-containing cells in epithelia during normal development and during the development of epithelial neoplasms. Cytokeratin OSCAR is a broad-spectrum marker react with type I and type II low molecular weight cytokeratins 7, 8, 18 and 19 (additional cytokeratins may also be detected)."}]}]}