{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Cytokeratins are intermediate-filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue. There are two types of cytokeratins: acidic type I cytokeratins and basic or neutral type II cytokeratins. Cytokeratins are usually found in pairs comprising a type I cytokeratin and a type II cytokeratin. Expression of these cytokeratins is frequently organ or tissue specific. AE1 and AE3 is a cocktail of 2 different clones of cytokeratin antibodies, which function as a broad spectrum cytokeratin marker to study the the distribution of keratin-containing cells in epithelia during normal development and during the development of epithelial neoplasms. AE1 detects the high molecular weight cytokeratins 10, 14, 15 and 16 and the low molecular weight cytokeratin 19. AE3 detects the high molecular weight cytokeratins 1, 2, 3, 4, 5 and 6 and the low molecular weight cytokeratins 7 and 8. Not reactive to cytokeratins 17 and 18."}]}]}