{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Cytokeratins are intermediate-filament keratins found in the intracytoplasmic cytoskeleton of epithelial tissue. There are two types of cytokeratins: acidic type I cytokeratins and basic or neutral type II cytokeratins. Cytokeratins are usually found in pairs comprising a type I cytokeratin and a type II cytokeratin. Expression of these cytokeratins is frequently organ or tissue specific. Cytokeratin 17 (CK17) is a type I acidic high molecular weight intermediate filament protein found in epithelial cells, particularly in basal and myoepithelial cells. It plays a role in maintaining cell structure, regulating cell growth, and participating in various signaling pathways. Cytokeartin 17 is often studied together with cytokeratin 7 in the context of disease, particularly cancer, due to their different expression patterns and potential clinical significance."}]}]}