{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"CD79a is non-covalently associated with membrane-bound immunoglobulins on B-cells to constitute the B-cell antigen receptor. CD79a first appears at the pre B-cell stage and persists until the plasma-cell stage, where it is found as an intracellular component. CD79a is found in the majority of acute leukemias of precursor B-cell type, in B-cell lines, B-cell lymphomas, and in some myelomas according to literature. CD79a is a B-cell marker that is generally used to complement CD20."}]}]}