{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"Ecto-5’-nucleotidase (NT5E), or also known as CD73, encoded by the NT5E gene on the human chromosome 6q14.3, is a dimer of two identical 70 kDa subunits. The mature form of CD73 has a molecular weight of 61 kDa. As a plasma membrane protein and expressed in various cell types, CD73 hydrolyzes extracellular adenosine monophosphate into adenosine and inorganic phosphate. It performs homeostatic functions and plays an important role in immunity and inflammation. In cells of the immune system, CD73, in combination with CD39, serves as an immunological switch that turns the cell activity from pro-inflammatory toward anti-inflammatory, which is mediated by adenosine. CD73 overexpression was found to be associated with several types of human cancers including bladder, brain, invasive lobular breast, esophageal, gastric, pancreatic, rectal mucinous, renal cell, lung large cell, oral cavity squamous cell, melanoma, and lung adenocarcinoma cancers according to literature."}]}]}