{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"CD34 functions as a cell-cell adhesion factor and cell-surface glycoprotein. It may also mediate the attachment of stem cells to bone marrow extracellular matrices or directly to stromal cells. Cells expressing CD34 are normally found in the umbilical cord and bone marrow as hematopoietic cells, and in vascular endothelium. In addition to stem cell recognition, CD34 is expressed by vascular endothelium; it appears that proliferating endothelial cells express this molecule in greater amounts than resting cells. In comparison to factor VIII R Antigen, CD34 stains are stronger and appear to be more sensitive in nature.According to literature, CD34 is expressed in a variety of tumors including alveolar soft part sarcoma, precursor B-cell acute lymphoblastic leukemia, acute myeloid leukemia, acute megakaryoblastic leukemia, dermatofibrosarcoma protuberans, gastrointestinal stromal tumors, giant cell fibroblastoma, granulocytic sarcoma, Kaposi’s sarcoma, liposarcoma, malignant fibrous histiocytoma, malignant peripheral nerve sheath tumors, meningeal hemangiopericytomas, meningiomas, neurofibromas, schwannomas, and papillary thyroid carcinoma.."}]}]}