{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"CD123, also known as IL-3Ra (Interleukin-3 receptor alpha), is the α subunit of the interleukin-3 (IL-3) receptor complex. It binds to IL-3 with rather low affinity. However, when associated with CD131 (common β chain), the protein binds to IL-3 with high affinity. The IL-3 receptor complex is primarily expressed on hematopoietic stem and progenitor cells and plays a crucial role in regulating hematopoiesis, particularly the production and differentiation of myeloid lineage cells. (e.g., granulocytes, monocytes, and dendritic cells).\nDysregulation of CD123 signaling can lead to aberrant myeloid cell proliferation and differentiation, contributing to the pathogenesis of hematological disorders such as acute myeloid leukemia (AML), myelodysplastic syndromes (MDS), and certain types of myeloproliferative neoplasms (MPNs)."}]}]}