{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"CD105/Endoglin is a Type I membrane glycoprotein located on cell surfaces and is part of the Transforming growth factor beta receptor complex. This protein has been found on endothelial cells, activated macrophages, fibroblasts, and smooth-muscle cells. Endoglin has a role in the development of the cardiovascular system and in vascular remodeling. Its expression is regulated during heart development. In humans, endoglin may be involved in the autosomal dominant disorder known as Hereditary Hemorrhagic Telangiectasia Type 1. CD105 is highly expressed in endothelial cells during tumor angiogenesis and inflammation, with weak or negative expression in vascular endothelium of normal tissues."}]}]}