{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"CD10, also known as neutral endopeptidase (NEP), Neprilysin, and common Acute Lymphoblastic Leukemia antigen (CALLA), is a zinc-dependent metalloprotease enzyme that degrades a number of small secreted peptides, most notably the amyloid beta peptide whose abnormal misfolding and aggregation in neural tissue has been implicated as a cause of Alzheimer’s Disease. CD10 is expressed in lymphoblastic, Burkitt’s, and follicular lymphomas, and chronic myelocytic leukemia. CD10 is also detected in the glomerular epithelial cells and the brush border of the proximal tubules. Non-lymphoid cells that express CD10 are breast myoepithelial cells, bile canaliculi, neutrophils, a small population of bone marrow cells, fetal small intestine epithelium, and normal fibroblasts."}]}]}