{"type":"root","children":[{"type":"paragraph","children":[{"type":"text","value":"CA19-9 or Sialyl Lewis A (sLeA) belong to a class of carbohydrate molecules that are known to mediate adhesion between tumor cells and endothelium by interacting as a selectin ligand by binding to E-selectin. CA19-9 was first discovered in patients with colon cancer and pancreatic cancer in 1981. Increased levels of CA19-9 are also found in non-malignant conditions, such as Mirizzi’s Syndrome and diseases of the bile duct and liver. CA19-9 is highly expressed in gastrointestinal (gastric, pancreatic, and colonic) adenocarcinomas and salivary gland mucoepidermoid carcinomas."}]}]}